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Codeine belongs to a group of medicines known as opioids. Codeine is used to reduce coughing, however opioids are primarily used in the treatment of pain, although may also be used in the treatment of restless legs syndrome and diarrhoea. Opioids bind to nerves throughout the body and will have a direct effect on the brain.
Codeine is broken down in the body (metabolised) by an enzyme in the liver known as CYP 2D6 into morphine, which is considered to provide the beneficial effects of the medicine. Some medicines will interact with this enzyme to either enhance its activity or inhibit its activity. Some people are also known to be able to metabolise codeine much better than others and will therefore be more susceptible to its effects.
Codeine Linctus is a cough syrup that helps to treat dry and tickly coughs. It decreases the urge to cough, leaving you feeling free from irritation caused by a persistent cough.It must not be used by anyone under 18 years old and do not exceed the stated dose.
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Codeine linctus is used recreationally to make a drink known as ‘Purple Drank’, ‘Lean’, ‘Dirty Sprite’ or ‘Sizzurp’ (herein collectively referred to as Purple Drank). Purple Drank is a mix of codeine linctus, promethazine (an antihistamine) and fizzy drinks, sometimes with boiled sweets to take away the bitterness of the linctus. Codeine provides the euphoria sought by users and the antihistamine is added to counteract any sensitivity reactions to codeine, however promethazine is also a sedative which can make users sleepy and lose track of how much codeine they have consumed. Recreational use of codeine carries serious risks and could result in loss of consciousness, respiratory suppression and death. Concomitant use with a central nervous system (CNS) depressant, such as alcohol, sedatives or other medicines, will further increase these risks.